Formulation and Evaluation of Thermo-Sensitive In Situ Gel of Brimonidine Tartrate

The intension behind the present work was formulation and evaluation of in situ gel of brimonidine tartrate. Brimonidine tartrate is an antiglaucomic agent which shows rapid precorneal exclusion and reduced ocular bioavailability when given in form of conventional ophthalmic formulations. To avoid this, an attempt has been made to formulate thermosensitive in situ gel of brimonidine tartrate to provide sustained release based on excipients that shows phase change from sol-to-gel upon change in temperature. The Brimonidine tartrate in situ gel was formulated by using triblock co-polymer (Poloxamer 407) as thermoreversible agent along with chitosan as mucoadhesive agent. On the basis of interaction studies, all physico-chemical study, sterility test and stability studies, it can be concluded that this in situ gel formulation provided the desired drug release and remained stable and intact at ambient conditions.